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Better early osteogenesis of electroconductive hydroxyapatite-calcium titanate composites in a rabbit animal model

Mallik, Prafulla Kumar and Basu, Bikramjit (2014) Better early osteogenesis of electroconductive hydroxyapatite-calcium titanate composites in a rabbit animal model. In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 102 (3). pp. 842-851.

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Official URL: http://dx.doi.org/10.1002/jbm.a.34752


In view of the fact that bone healing can be enhanced due to external electric field application, it is important to assess the influence of the implant conductivity on the bone regeneration in vivo. To address this issue, this study reports the in vivo biocompatibility property of multistage spark plasma sintered hydroxyapatite (HA)-80 wt % calcium titanate (CaTiO3) composites and monolithic HA, which have widely different conductivity property (14 orders of magnitude difference). The ability of bone regeneration was assessed by implantation in cylindrical femoral bone defects of rabbit animal model for varying time period of 1, 4, and 12 weeks. The overall assessment of the histology results suggests that the progressive healing of bone defects around HA-80 wt % CaTiO3 is associated with a better efficacy with respect to (w.r.t) early stage neobone formation, which is histomorphometrically around 140% higher than monolithic HA. Overall, this study demonstrates that the in vivo biocompatibility property of HA-80 wt % CaTiO3 with respect to local effects after 12 weeks of implantation is not compromised both qualitatively and quantitatively, and a comparison with control implant (HA) points toward the critical role of electrical conductivity on better early stage bone regeneration. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 842-851, 2014.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the WILEY-BLACKWELL,USA
Keywords: HA; calcium titanate; electrical conductivity; in vivo biocompatibility
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Depositing User: Id for Latest eprints
Date Deposited: 10 Feb 2014 10:26
Last Modified: 10 Feb 2014 10:26
URI: http://eprints.iisc.ac.in/id/eprint/48352

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