Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide beta-hairpins

Makwana, Kamlesh Madhusudan and Raghothama, Srinivasarao and Mahalakshmi, Radhakrishnan (2013) Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide beta-hairpins. In: PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 15 (37). pp. 15321-15324.

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Abstract

The contribution of Tyr-His vs. Cys-His interacting pairs to the scaffold stability of (D)Pro-(L)Pro nucleated peptide beta-hairpins has been examined. We present direct evidence for the superiority of the Cys-His pairs, mediated by sulphur-imidazole interactions, as added stabilizing agents of the beta-hairpin scaffold.

Item Type:	Journal Article
Publication:	PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright of this Article belongs to RSC
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	08 Oct 2013 11:24
Last Modified:	08 Oct 2013 11:24
URI:	http://eprints.iisc.ac.in/id/eprint/47455

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