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Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles

Swapna, Mukkara and Premakumari, Chokkappagari and Reddy, Sanapalli Nagi and Padmaja, Adivireddy and Padmavathi, Venkatapuram and Kondaiah, Paturu and Krishna, Narra Siva (2013) Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles. In: CHEMICAL & PHARMACEUTICAL BULLETIN, 61 (7). pp. 722-730.

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Official URL: http://dx.doi.org/10.1248/cpb.c13-00218

Abstract

A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penieillium ehrysogenunz. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to PHARMACEUTICAL SOC JAPAN
Keywords: 1,3,4-oxadiazole; 1,3,4-thiadiazole; pyrrole; pyrazole; antimicrobial activity; cytotoxicity
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Depositing User: Id for Latest eprints
Date Deposited: 04 Sep 2013 06:49
Last Modified: 04 Sep 2013 06:51
URI: http://eprints.iisc.ac.in/id/eprint/47044

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