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Antibody-mediated catalysis: Induction and therapeutic relevance

Mahendra, Ankit and Sharma, Meenu and Rao, Desirazu N and Peyron, Ivan and Planchais, Cyril and Dimitrov, Jordan D and Kaveri, Srini V and Lacroix-Desmazes, Sebastien (2013) Antibody-mediated catalysis: Induction and therapeutic relevance. In: Autoimmunity Reviews, 12 (6). pp. 648-652.

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Official URL: http://dx.doi.org/10.1016/j.autrev.2012.10.009


Abzymes are immunoglobulins endowed with enzymatic activities. The catalytic activity of an abzyme resides in the variable domain of the antibody, which is constituted by the close spatial arrangement of amino acid residues involved in catalysis. The origin of abzymes is conferred by the innate diversity of the immunoglobulin gene repertoire. Under deregulated immune conditions, as in autoimmune diseases, the generation of abzymes to self-antigens could be deleterious. Technical advancement in the ability to generate monoclonal antibodies has been exploited in the generation of abzymes with defined specificities and activities. Therapeutic applications of abzymes are being investigated with the generation of monoclonal abzymes against several pathogenesis-associated antigens. Here, we review the different contexts in which abzymes are generated, and we discuss the relevance of monoclonal abzymes for the treatment of human diseases.

Item Type: Journal Article
Publication: Autoimmunity Reviews
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Catalytic Antibodies; Abzymes; Autoimmune Diseases; Abzyme Therapy
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Jul 2013 06:30
Last Modified: 11 Jul 2013 06:30
URI: http://eprints.iisc.ac.in/id/eprint/46825

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