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Dual enzyme responsive microcapsules simulating an ``OR'' logic gate for biologically triggered drug delivery applications

Radhakrishnan, Krishna and Tripathy, Jasaswini and Raichur, Ashok M (2013) Dual enzyme responsive microcapsules simulating an ``OR'' logic gate for biologically triggered drug delivery applications. In: Chemical Communications, 49 (47). pp. 5390-5392.

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Official URL: http://dx.doi.org/10.1039/C3CC42017E

Abstract

Hollow microcapsules capable of disintegrating in response to dual biological stimuli have been synthesized from two FDA approved drug molecules. The capsules fabricated from protamine and chondroitin sulphate disintegrate in the presence of either trypsin or hyaluronidase enzymes, which are documented to be simultaneously over-expressed under some pathological conditions.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Francis Jayakanth
Date Deposited: 05 Jul 2013 06:07
Last Modified: 05 Jul 2013 06:07
URI: http://eprints.iisc.ac.in/id/eprint/46800

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