Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides

Srinivas, Oruganti and Radhika, S and Bandaru, Narasimha Murthy and Nadimpalli, Siva Kumar and Jayaraman, Narayanaswamy (2005) Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides. In: Organic & Biomolecular Chemistry, 3 (23). pp. 4252-4257.

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Abstract

The synthesis of multivalent dendritic cluster glycosides of mannopyranosyl-6-phosphate is presented. Poly( amido amine)-based dendrimers of 0.5-3.5 generations, containing carboxylic acid peripheral functionalities, were utilized so as to install 4, 8, 16 and 32 mannopyranosyl-6-phosphate residues at the peripheries of the dendrimers. Amide bond formation between an amine-tethered mannopyranosyl-6-phosphate monomer unit and carboxylic acid-functionalized dendrimers was conducted to synthesize the dendritic cluster glycosides. The constitutions of the Man-6-P-containing dendrimers were assessed by $^{1}H, ^{13}C$ and $^{31}P$ NMR spectroscopies and the sugar content analysis by a resorcinol assay. Preliminary biological studies with few newly synthesized Man-6-P-containing dendrimers showed that these compounds could bind the purified goat liver mannose 6-phopshate receptor (MPR 300) protein.

Item Type:	Journal Article
Publication:	Organic & Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	16 Dec 2005
Last Modified:	19 Sep 2010 04:22
URI:	http://eprints.iisc.ac.in/id/eprint/4680

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