Goswami, Tridib K and Gadadhar, Sudarshan and Karande, Anjali A and Chakravarty, Akhil R (2013) Photocytotoxic ferrocene-appended (L-tyrosine)copper(II) complexes of phenanthroline bases. In: Polyhedron, 52 (SI). pp. 1287-1298.
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Abstract
Copper(II) complexes of ferrocene(Fc)-conjugated reduced Schiff base of L-tyrosine (Fc-TyrH), viz., Cu(Fc-Tyr)(L)](ClO4), where L is 1,10-phenanthroline (phen, 1), dipyrido3,2-d:2',3'-f]quinoxaline (dpq, 2), dipyrido3,2-a:2',3'-c]phenazine (dppz, 3) and 2-(naphthalen-1-yl)-1H-imidazo4,5-f]1,10]phenanthroline (nip, 4), were prepared and tested for their photocytotoxicity in cancer cells. Cu(Fc-Phe)(phen)](-ClO4) (5) of L-phenylalanine and Cu(Ph-Tyr)(L)(ClO4)] of the reduced Schiff base Ph-TyrH derived from benzaldehyde and L-tyrosine having phen (6) and dppz (7), and Cu(Ph-Phe)(phen)(ClO4)] (8) using L-phenylalanine were prepared and used as controls. Complexes 5 and 6 were structurally characterized by X-ray crystallography. A copper(II)-based d-d band near 600 nm and a ferrocenyl band at similar to 450 nm were observed in DMF-Tris-HCI buffer (1:4 v/v) in respective complexes. The complexes are photocleavers of pUC19 DNA in visible light forming (OH)-O-center dot radicals. They are cytotoxic in HeLa (human cervical cancer) and MCF-7 (human breast cancer) cells showing an enhancement of cytotoxicity in visible light. Fluorescence imaging shows nuclear localization of the complexes.
Item Type: | Journal Article |
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Publication: | Polyhedron |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Ferrocene; Copper; Crystal Structure; DNA Photocleavage; Photocytotoxicity; Cellular Imaging |
Department/Centre: | Division of Biological Sciences > Biochemistry Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 23 Jun 2013 09:42 |
Last Modified: | 23 Jun 2013 09:42 |
URI: | http://eprints.iisc.ac.in/id/eprint/46761 |
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