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Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules

Thomas, Midhun B and Radhakrishnan, Krishna and Gnanadhas, Divya P and Chakravortty, Dipshikha and Raichur, Ashok M (2013) Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules. In: International Journal of Nanomedicine, 8 . pp. 267-273.

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Official URL: http://dx.doi.org/10.2147/IJN.S37737

Abstract

A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 +/- 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule happens by virtue of the pH-responsive property of the capsule wall, which is determined by the pKa of the polyelectrolytes. As the pH is varied, about 64% of the drug is released in acidic pH while 77% is released in neutral pH. The biocompatibility, efficiency of drug loading, and enhanced bioavailability of the capsule system was confirmed by MTT assay and in vivo biodistribution studies.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Dove Medical Press Ltd.
Keywords: Drug Delivery; Layer-by-Layer; Electrostatic Interaction; Biocompatible
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Francis Jayakanth
Date Deposited: 10 Jun 2013 07:46
Last Modified: 10 Jun 2013 07:46
URI: http://eprints.iisc.ac.in/id/eprint/46672

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