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A cyclic peptide mimic of an RNA recognition motif of human La protein is a potent inhibitor of hepatitis C virus

Manna, Asit Kumar and Kumar, Anuj and Ray, Upasana and Das, Saumitra and Basu, Gautam and Roy, Siddhartha (2013) A cyclic peptide mimic of an RNA recognition motif of human La protein is a potent inhibitor of hepatitis C virus. In: Antiviral Research, 97 (3). pp. 223-226.

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Official URL: http://dx.doi.org/10.1016/j.antiviral.2012.12.026

Abstract

Due to limited available therapeutic options, developing new lead compounds against hepatitis C virus is an urgent need. Human La protein stimulates hepatitis C virus translation through interaction with the hepatitis C viral RNA. A cyclic peptide mimicking the beta-turn of the human La protein that interacts with the viral RNA was synthesized. It inhibits hepatitis C viral RNA translation significantly better than the corresponding linear peptide at longer post-treatment times. The cyclic peptide also inhibited replication as measured by replicon RNA levels using real time RT-PCR. The cyclic peptide emerges as a promising lead compound against hepatitis C.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Cyclic Peptide; HCV Tranlation; Replicon; Beta-Turn
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Francis Jayakanth
Date Deposited: 28 May 2013 06:59
Last Modified: 28 May 2013 06:59
URI: http://eprints.iisc.ac.in/id/eprint/46585

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