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Chromosomal translocations among the healthy human population: implications in oncogenesis

Nambiar, Mridula and Raghavan, Sathees C (2013) Chromosomal translocations among the healthy human population: implications in oncogenesis. In: CELLULAR AND MOLECULAR LIFE SCIENCES, 70 (8). pp. 1381-1392.

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Official URL: http://dx.doi.org/10.1007/s00018-012-1135-x

Abstract

Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried out in different geographical areas of the world and discuss the relevance of the observation with respect to oncogenesis.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the SPRINGER BASEL AG, SWITZERLAND.
Keywords: Leukemia; Lymphoma; Neoplasia; Carcinoma; Sarcoma; Genomic instability; V(D)J recombination
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Francis Jayakanth
Date Deposited: 01 May 2013 10:14
Last Modified: 01 May 2013 10:14
URI: http://eprints.iisc.ac.in/id/eprint/46453

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