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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Mishra, Aseem and Misra, Anurag and Vaishnavi, SriT and Thota, Chaitanya and Gupta, Madhvi and Ramakumar, Suryanarayanarao and Chauhan, VS (2013) Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization. In: CHEMICAL COMMUNICATIONS, 49 (26). pp. 2688-2690.

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Official URL: http://dx.doi.org/10.1039/c3cc38982k

Abstract

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic beta-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (Delta F) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects beta-cells from hIAPP induced toxicity.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the ROYAL SOC CHEMISTRY, ENGLAND.
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Depositing User: Francis Jayakanth
Date Deposited: 09 Apr 2013 05:53
Last Modified: 01 Mar 2019 07:07
URI: http://eprints.iisc.ac.in/id/eprint/46329

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