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Synthesis, characterization and phosphotriesterase mimetic activity of some Zn(II) and Cu(II) complexes

Singh, Mamata and Butcher, Ray J and Jasinski, Jerry P and Golen, James A and Mugesh, Govindasamy (2012) Synthesis, characterization and phosphotriesterase mimetic activity of some Zn(II) and Cu(II) complexes. In: JOURNAL OF CHEMICAL SCIENCES, 124 (6, SI). pp. 1301-1313.

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Official URL: http://dx.doi.org/10.1007/s12039-012-0331-4

Abstract

We report here the synthesis and characterization of a few phenolate-based ligands bearing tert- amino substituent and their Zn(II) and Cu(II) metal complexes. Three mono/binuclear Zn(II) and Cu(II) complexes Zn(L1)(H2O)].CH3OH.H2O (1) (H (2) L1 = 6,6(')-(((2-dimethylamino)ethylazanediyl)bis(methylene))bis(2, 4-dimethylphenol), Zn-2(L2)(2)] (2) (H (2) L2 = 2,2(')-(((2-dimethylamino)ethyl)azanediyl)bis(methylene)bis(4- methylphenol) and Cu-2(L3)(2).CH2 Cl-2] (3) (H (2) L3 = (6,6(')-(((2-(diethylamino)ethyl)azanediyl)bis(methylene)) bis(methylene))bis(2,4-dimethylphenol) were synthesized by using three symmetrical tetradendate ligands containing N2O2 donor sites. These complexes are characterized by a variety of techniques including; elemental analysis, mass spectrometry, H-1, C-13 NMR spectroscopic and single crystal X-ray analysis. The new complexes have been tested for the phosphotriesterase (PTE) activity with the help of P-31 NMR spectroscopy. The P-31 NMR studies show that mononuclear complex Zn(L1)(H2O)].CH3OH.H2O (1) can hydrolyse the phosphotriester i.e., p-nitrophenyl diphenylphosphate (PNPDPP), more efficiently than the binuclear complexes Zn-2(L2)(2)] (2) and Cu-2(L3)(2).CH2Cl2] (3). The mononuclear Zn(II) complex (1) having one coordinated water molecule exhibits significant PTE activity which may be due to the generation of a Zn(II)-bound hydroxide ion during the hydrolysis reactions in CHES buffer at pH 9.0.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to INDIAN ACAD SCIENCES, BANGALORE, INDIA
Keywords: Bis-phenolate ligand;Zn(II) complex;mononuclear complex;binuclear complex;crystal structure;PTE activity
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Francis Jayakanth
Date Deposited: 19 Feb 2013 05:12
Last Modified: 19 Feb 2013 05:12
URI: http://eprints.iisc.ac.in/id/eprint/45833

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