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Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch

Singh, Akhilesh Vikram and Nath, Lila Kanta (2013) Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch. In: EXPERT OPINION ON DRUG DELIVERY, 10 (2). pp. 173-182.

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Official URL: http://dx.doi.org/10.1517/17425247.2013.738665

Abstract

Objectives: Modified starches based polymeric substances find utmost applicability in pharmaceutical formulation development. Cross-linked starches showed very promising results in drug delivery application. The present investigation concerns with the development of controlled release tablets of lamivudine using cross-linked sago starch. Methods: The cross-linked derivative was synthesized with phosphorous oxychloride and native sago starch in basic pH medium. The cross-linked sago starch was tested for acute toxicity and drug-excipient compatibility study. The formulated tablets were evaluated for various physical characteristics, in vitro dissolution release study and in vivo pharmacokinetic study in rabbit model. Results: In vitro release study showed that the optimized formulation exhibited highest correlation (R) in case of zero order kinetic model and the release mechanism followed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T-max, C-max, AUC, V-d, T-1/2, and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir (R). Conclusion: The cross-linked starch showed promising results in terms of controlling the release behavior of the active drug from the matrix. The hydrophilic matrix synthesized by cross-linking could be used with a variety of active pharmaceutical ingredients for making their controlled/sustained release formulations.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to INFORMA HEALTHCARE, ENGLAND
Keywords: controlled release;cross-linked starch;lamivudine;pharmacokinetic
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Francis Jayakanth
Date Deposited: 18 Feb 2013 09:02
Last Modified: 19 Feb 2013 05:03
URI: http://eprints.iisc.ac.in/id/eprint/45811

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