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Single nucleotide polymorphisms in genes that are common targets of luteotropin and luteolysin in primate corpus luteum: Computational exploration

Suresh, Padmanaban S and Venkatesh, Thejaswini and Rajan, Thangarasu (2012) Single nucleotide polymorphisms in genes that are common targets of luteotropin and luteolysin in primate corpus luteum: Computational exploration. In: GENE, 511 (2). pp. 353-357.

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Official URL: http://dx.doi.org/10.1016/j.gene.2012.09.076

Abstract

Luteal insufficiency affects fertility and hence study of mechanisms that regulate corpus luteum (CL) function is of prime importance to overcome infertility problems. Exploration of human genome sequence has helped to study the frequency of single nucleotide polymorphisms (SNPs). Clinical benefits of screening SNPs in infertility are being recognized well in recent times. Examining SNPs in genes associated with maintenance and regression of CL may help to understand unexplained luteal insufficiency and related infertility. Publicly available microarray gene expression databases reveal the global gene expression patterns in primate CL during the different functional state. We intend to explore computationally the deleterious SNPs of human genes reported to be common targets of luteolysin and luteotropin in primate CL Different computational algorithms were used to dissect out the functional significance of SNPs in the luteinizing hormone sensitive genes. The results raise the possibility that screening for SNPs might be integrated to evaluate luteal insufficiency associated with human female infertility for future studies. (C) 2012 Elsevier B.V. All rights reserved,

Item Type: Journal Article
Additional Information: Copyright for this article belongs to ELSEVIER SCIENCE BV, NETHERLANDS
Keywords: Corpus luteum;SNP;Microarray
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Depositing User: Francis Jayakanth
Date Deposited: 15 Feb 2013 12:09
Last Modified: 15 Feb 2013 12:09
URI: http://eprints.iisc.ac.in/id/eprint/45782

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