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The origins of the evolutionary signal used to predict protein-protein interactions

Swapna, Lakshmipuram S and Srinivasan, Narayanaswamy and Robertson, David L and Lovell, Simon C (2012) The origins of the evolutionary signal used to predict protein-protein interactions. In: BMC EVOLUTIONARY BIOLOGY, 12 .

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Official URL: http://dx.doi.org/10.1186/1471-2148-12-238


Background: The correlation of genetic distances between pairs of protein sequence alignments has been used to infer protein-protein interactions. It has been suggested that these correlations are based on the signal of co-evolution between interacting proteins. However, although mutations in different proteins associated with maintaining an interaction clearly occur (particularly in binding interfaces and neighbourhoods), many other factors contribute to correlated rates of sequence evolution. Proteins in the same genome are usually linked by shared evolutionary history and so it would be expected that there would be topological similarities in their phylogenetic trees, whether they are interacting or not. For this reason the underlying species tree is often corrected for. Moreover processes such as expression level, are known to effect evolutionary rates. However, it has been argued that the correlated rates of evolution used to predict protein interaction explicitly includes shared evolutionary history; here we test this hypothesis. Results: In order to identify the evolutionary mechanisms giving rise to the correlations between interaction proteins, we use phylogenetic methods to distinguish similarities in tree topologies from similarities in genetic distances. We use a range of datasets of interacting and non-interacting proteins from Saccharomyces cerevisiae. We find that the signal of correlated evolution between interacting proteins is predominantly a result of shared evolutionary rates, rather than similarities in tree topology, independent of evolutionary divergence. Conclusions: Since interacting proteins do not have tree topologies that are more similar than the control group of non-interacting proteins, it is likely that coevolution does not contribute much to, if any, of the observed correlations.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to BIOMED CENTRAL LTD, ENGLAND
Keywords: Co-evolution;Correlated evolution;Protein evolution;Phylogenetic;Protein-protein complexes;Protein-protein interactions
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Francis Jayakanth
Date Deposited: 04 Feb 2013 10:57
Last Modified: 04 Feb 2013 10:57
URI: http://eprints.iisc.ac.in/id/eprint/45732

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