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Chiral discrimination and the measurement of enantiomeric excess from a severely overcrowded NMR spectrum

Chaudhari, Sachin Rama and Suryaprakash, N (2013) Chiral discrimination and the measurement of enantiomeric excess from a severely overcrowded NMR spectrum. In: CHEMICAL PHYSICS LETTERS, 555 . pp. 286-290.

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Official URL: http://dx.doi.org/10.1016/j.cplett.2012.10.085

Abstract

NMR spectroscopic chiral visualization, unambiguous assignment of peaks pertaining to R and S enantiomers and the subsequent measurement of enantiomeric composition demands a highly resolved spectrum. The method fails when the spectrum is severely overcrowded or highly complex, thereby hampering the determination of enantiomeric excess. In order to circumvent such problems we propose the utility of pure shift spectrum obtained by resolving the chemical shift and coupling information in two orthogonal dimensions. The skew projected spectrum yields singlet's at the respective chemical shift positions, permitting the unravelling of the superimposed spectral transitions for each enantiomer and measurement of enantiomeric composition. (C) 2012 Elsevier B. V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to ELSEVIER SCIENCE BV, NETHERLANDS
Department/Centre: Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Francis Jayakanth
Date Deposited: 06 Feb 2013 12:17
Last Modified: 28 Feb 2019 11:58
URI: http://eprints.iisc.ac.in/id/eprint/45710

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