Photo-induced anticancer activity of polypyridyl platinum(II) complexes

Maity, Basudev and Gadadhar, Sudarshan and Goswami, Tridib K and Karande, Anjali A and Chakravarty, Akhil R (2012) Photo-induced anticancer activity of polypyridyl platinum(II) complexes. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 57 . pp. 250-258.

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Abstract

Polypyridyl platinum(II) complexes (1-5), viz., Pt(pyphen)Cl]Cl (1), Pt(pyphen)(C CFc)]Cl (2), Pt(pydppz)Cl]Cl (3), Pt(pydppz)(C CPh)]Cl (4) and Pt(pydppz)(C CFc)]Cl (5), where pyphen is 6-(2-pyridyl)-1,10-phenanthroline, pydppz is 6-(2-pyridyl)-dipyrido-3,2-a:2',3'-c]-phenazine, FcC CH is ferrocenyl acetylene and PhC CH is phenyl acetylene, were synthesized, characterized and their DNA binding and photocytotoxic properties studied. The complexes showed strong binding affinity to calf-thymus DNA giving K-app of similar to 10(6)-10(7) M-1. Complexes 4 and 5 showed dual mode of binding to ct-DNA. The pydppz complexes 3-5 having a photoactive phenazine moiety showed photocytotoxicity in HeLa and MCF-7 cells in UV-A light of 365 nm with apoptotic cell death as evidenced from the acridine orange/ethidium bromide dual staining and the FACS data. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Additional Information:	Copyright for this article belongs to ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, FRANCE
Keywords:	Medicinal chemistry;Platinum;Ferrocene conjugates;DNA binding;Photocytotoxicity;Apoptosis
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	29 Jan 2013 12:31
Last Modified:	29 Jan 2013 12:31
URI:	http://eprints.iisc.ac.in/id/eprint/45702

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