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Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety

Adhikari, Adithya and Kalluraya, Balakrishna and Sujith, Kizhakke Veedu and Gouthamchandra, Kuluvar and Jairam, Ravikumar and Mahmood, Riaz and Sankolli, Ravish (2012) Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 55 . pp. 467-474.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2012.07.002

Abstract

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-Pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier Science, FRANCE
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Francis Jayakanth
Date Deposited: 13 Dec 2012 05:31
Last Modified: 13 Dec 2012 05:31
URI: http://eprints.iisc.ac.in/id/eprint/45503

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