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Naphthylhydrazone based selective and sensitive chemosensors for Cu2+ and their application in bioimaging

Anbu, Sellamuthu and Shanmugaraju, Sankarasekaran and Ravishankaran, Rajendran and Karande, Anjali A and Mukherjee, Partha Sarathi (2012) Naphthylhydrazone based selective and sensitive chemosensors for Cu2+ and their application in bioimaging. In: Dalton Transactions, 41 (43). pp. 13330-13337.

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Official URL: http://dx.doi.org/10.1039/C2DT31335A

Abstract

Two new hydroxynaphthyl-hydrazone based fluorogenic chemosensors R-1 and R-2 have been synthesized by Schiff base condensation of Tris(4-formylphenyl)amine with 1-hydroxynaphthalene-2-hydrazide and 1-hydroxynaphthalene-2-carbohydrazone, respectively. They are examined as highly selective and sensitive receptors for Cu2+ ions in aqueous medium. Electronic absorption as well as fluorescence titration studies of receptors R-1 and R-2 with different metal cations in H2O/CH3CN medium showed highly selective and very rapid (< 2 min) binding affinity towards Cu2+ ions even in the presence of other commonly coexisting metal ions such as Na+, K+, Mg2+, Ca2+, Mn2+, Fe2+, Co2+, Ni2+, Zn2+, Cd2+ and Hg2+. Quantification of the fluorescence titration analysis indicated that these newly synthesized receptors (R-1 and R-2) can indicate the presence of Cu2+ ions even at very low concentrations of 598 and 676 ppt, respectively. In addition, the propensity of these receptors as bio-imaging fluorescent probes to detect Cu2+ ions in human cervical HeLa cancer cell lines and their cytotoxicity against HeLa cells have been investigated.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 26 Feb 2013 12:25
Last Modified: 26 Feb 2013 12:25
URI: http://eprints.iisc.ac.in/id/eprint/45416

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