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Synthesis and structural characterization of some trisulfide analoges of thiouracil-based antithyroid drugs

Bhabak, Krishna P and Bhowmick, Debasish (2012) Synthesis and structural characterization of some trisulfide analoges of thiouracil-based antithyroid drugs. In: JOURNAL OF MOLECULAR STRUCTURE, 1022 . pp. 16-24.

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Official URL: http://dx.doi.org/10.1016/j.molstruc.2012.05.005

Abstract

Thiourea-based antithyroid drugs are effectively used for the treatment of hyperthyroidism. In this paper, we describe the synthesis of new trisulfides (11-12) from the commonly used thiourea-based antithyroid drugs such as 6-n-propyl-2-thiouracil (PTU) and 6-methyl-2-thiouracil (MTU) in the reaction with I-2/KI system. Structural analysis by single crystal X-ray diffraction studies revealed the stabilization of trisulfides by a lactam-lactim tautomerism facilitating effective intramolecular as well as intermolecular non-covalent interactions. Although the structures of both trisulfides were found to be quite similar, a notable difference in the intermolecular interactions was observed between compounds 11 and 12 leading to different structural patterns. Structural stabilization of these trisulfides by tautomerism followed by intramolecular as well as intermolecular H-bonds makes these molecules as perfect examples in molecular recognition with self-complementary donor and acceptor units within a single molecule. (C) 2012 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to ELSEVIER SCIENCE BV
Keywords: Antithyroid drugs;Tautomerism; H-bond;Trisulfides;Iodine
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 12 Dec 2012 07:10
Last Modified: 13 Dec 2012 10:48
URI: http://eprints.iisc.ac.in/id/eprint/45235

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