Micellar aggregates and hydrogels from phosphonobile salts

Babu, Ponnusamy and Chopra, D and Row, Guru TN and Maitra, Uday (2005) Micellar aggregates and hydrogels from phosphonobile salts. In: Organic & Biomolecular Chemistry, 3 (20). pp. 3695-3700.

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Abstract

The aggregation properties of novel bile acid analogs-phosphonobile salts (PBS)-have been studied. The critical micellar concentration of 23 and 24-phosphonobile salts were measured using fluorescence and P-31 NMR methods. All the ten synthesized phosphonobile salts formed gels at different pH ranges in water. The pH range at which individual PBSs could gelate water was narrow and influenced by the number and conformation of hydroxyl groups. A reversible thermochromic system has been developed (with 23-phosphonode oxycholate at pH 3.3), which changes color upon gelation. The investigation of the first hydrogels derived from trihydroxy bile acid analogs I and 6 was made using fluorescence,P-31 NMR, X-ray crystallography, circular dichroism and SEM. The present studies reveal that the gel network consists of a chiral,fibrous structure possessing hydrophobic interiors.

Item Type:	Journal Article
Publication:	Organic & Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit Division of Chemical Sciences > Organic Chemistry
Date Deposited:	12 Dec 2005
Last Modified:	19 Sep 2010 04:22
URI:	http://eprints.iisc.ac.in/id/eprint/4428

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