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Utilizing Model Nanostructured Porous Inorganic Compounds Such as Silica to Beneficially Confine “Bio”-Relevant Molecules and Demonstrate their Potential in Therapeutics

Bhattacharyya, Aninda J and Mandal, Soumit S (2011) Utilizing Model Nanostructured Porous Inorganic Compounds Such as Silica to Beneficially Confine “Bio”-Relevant Molecules and Demonstrate their Potential in Therapeutics. In: Journal of the Indian Institute of Science, 91 (4). pp. 485-496.

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Abstract

Abstract | The importance of well-defined inorganic porous nanostructured materials in the context of biotechnological applications such as drug delivery and biomolecular sensing is reviewed here in detail. Under optimized conditions, the confinement of “bio”-relevant molecules such as pharmaceutical drugs, enzymes or proteins inside such inorganic nanostructures may be remarkably beneficial leading to enhanced molecular stability, activity and performance. From the point of view of basic research, molecular confinement inside nanostructures poses several formidable and intriguing problems of statistical mechanics at the mesoscopic scale. The theoretical comprehension of such non-trivial issues will not only aid in the interpretation of observed phenomena but also help in designing better inorganic nanostructured materials for biotechnological applications.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to The Indian Institute of Science (IISc).
Keywords: Nanostructured porous inorganics;confinement;mesoporous oxides;oxide nanotubes;surface chemistry;controlled drug release;enzyme/protein biosensing.
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Ms TV Yashodha
Date Deposited: 09 Feb 2012 10:18
Last Modified: 09 Feb 2012 10:18
URI: http://eprints.iisc.ac.in/id/eprint/43239

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