Synthesis and characterization of some gold(I)-thiolate complexes having N-methylimidazole moiety

Bhabak, Krishna P and Mugesh, Govindasamy (2011) Synthesis and characterization of some gold(I)-thiolate complexes having N-methylimidazole moiety. In: Indian Journal of Chemistry - Section A: Inorganic, Physical, Theoretical and Analytical Chemistry, 50 (9-10, ). pp. 1303-1307.

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Abstract

Antithyroid drugs inhibit the thyroid hormone synthesis by inactivating the thyroid peroxidase and/or iodothyronine deiodinase, which are involved in iodination and deiodination reactions. Gold(I) compounds also inhibit the thyroid hormone synthesis by interacting with the selenocysteine residue of iodothyronine deiodinase. However, the chemical reactions between these two different classes of compounds have not been studied. In this paper, we describe the interaction of therapeutic gold(I) compounds with the commonly used thiourea-based antithyroid drug, methimazole. It is observed that the gold(I) phosphine complexes (R(3)PAuCl, where R = Me, Et, Ph) react with methimazole only upon deprotonation to produce the corresponding gold(I)-thiolate complexes. Addition of PPh(3) to the gold(I)-thiolates produces (R(3)PAuPPh(3))(+) (R = Me or Et), indicating the possibility of ligand exchange reactions.

Item Type:	Journal Article
Publication:	Indian Journal of Chemistry - Section A: Inorganic, Physical, Theoretical and Analytical Chemistry
Publisher:	National Institute of Science Communication and Information Resources
Additional Information:	Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Keywords:	Gold thiolate;Thiolates;Antithyroid drugs;Antiarthritic drugs;Methimazole;Ligand exchange;Rheumatoid arthritis
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	20 Dec 2011 11:50
Last Modified:	20 Dec 2011 11:51
URI:	http://eprints.iisc.ac.in/id/eprint/42786

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