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The Mathematical modeling of inhomogeneites in ventricular tissue

Shajahan, TK and Sinha, S and Pandit, R (2007) The Mathematical modeling of inhomogeneites in ventricular tissue. In: Proceedings of the Conference on Complex Dynamics of Physiological Systems: From Heart to Brain held at Presidency College, Kolkata, India, 12-14 February 2007, Kolkata, India.

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Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of spiral waves of electrical activation in cardiac tissue; unbroken spiral waves are associated with VT and broken ones with VF. Several experimental studies have been carried out to determine the effects of inhomogeneities in cardiac tissue on such arrhythmias. We give a brief overview of such experiments, and then an introduction to partial-differential-equation models for ventricular tissue. We show how different types of inhomogeneities can be included in such models, and then discuss various numerical studies, including our own, of the effects of these inhomogeneities on spiral-wave dynamics. The most remarkable qualitative conclusion of our studies is that the spiral-wave dynamics in such systems depends very sensitively on the positions of these inhomogeneities.

Item Type: Conference Paper
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 21 Oct 2011 04:57
Last Modified: 21 Oct 2011 04:57
URI: http://eprints.iisc.ac.in/id/eprint/41544

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