Grobelny, Pawel and Mukherjee, Arijit and Desiraju, Gautam R (2011) Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid. In: CrystEngComm, 13 (13). pp. 4358-4364.
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Abstract
Two drug-drug co-crystals of the anti-tuberculosis drugs isoniazid (INH), pyrazinamide (PYR) and 4-aminosalicylic acid (PAS) are reported. The first is the 1 : 1 molecular complex of INH and PAS. The second is the monohydrate of the 1 : 1 complex of PYR and PAS. The crystal structures of both co-crystals are characterized by a number of hydrogen bonded synthons. Hydrogen bonding of the COOH center dot center dot center dot N-pyridine type is found in both cases. In the INH : PAS co-crystal, there are two symmetry independent COOH center dot center dot center dot center dot N-pyridine hydrogen bonds. In one of these, the H-atom is located on the carboxylic group and is indicative of a co-crystal. In the second case, partial proton transfer occurs across the hydrogen bond, and the extent of proton transfer depends on the temperature. This is more indicative of a salt. Drug-drug co-crystals may have some bearing in the treatment of tuberculosis.
Item Type: | Journal Article |
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Publication: | CrystEngComm |
Publisher: | Royal Society of Chemistry |
Additional Information: | Copyright of this article belongs to Royal Society of Chemistry. |
Department/Centre: | Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
Date Deposited: | 04 Jul 2011 08:14 |
Last Modified: | 04 Jul 2011 08:14 |
URI: | http://eprints.iisc.ac.in/id/eprint/38888 |
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