Rao, KSJ and Ramesh, J and Easwaran, KRK (1999) Neuropeptide Y structure is modulated by aluminium in the hypothalamus. In: ALZHEIMERS REPORTS, 2 (2). 99-103 .
Full text not available from this repository. (Request a copy)Abstract
Aluminium is an element suspected to contribute to the pathogenesis of Alzheimer's disease, but its mechanism of action is not clear. Neuropeptide Y (NPY) plays a significant role in feeding behaviour. Our spectroscopic, ELISA, and western blot studies indicate that aluminium interacts with neuropeptide Y and alters significantly the a-helical content. We found that aluminium reduced levels of NPY in the hypothalamus of aged rabbits. NPY polyclonal antibody interaction was found to depend upon the alpha-helical content of NPY. These results clearly show that aluminium alters NPY structure and this could explain the abnormality in feeding behaviour seen in patients with Alzheimer's disease.
| Item Type: | Journal Article |
|---|---|
| Publication: | ALZHEIMERS REPORTS |
| Publisher: | MEDICAL SCIENCE JOURNALS |
| Additional Information: | Copyright of this article belongs to MEDICAL SCIENCE JOURNALS. |
| Keywords: | Alzheimers disease;aluminium;circular dichroism; conformation;neuropeptide |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 30 Jun 2011 09:01 |
| Last Modified: | 30 Jun 2011 09:01 |
| URI: | http://eprints.iisc.ac.in/id/eprint/38688 |
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