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Water-mediated ionic interactions in protein structures

Sabarinathan, R and Aishwarya, K and Sarani, R and Vaishnavi, Kirti M and Sekar, K (2011) Water-mediated ionic interactions in protein structures. In: Journal of Biosciences, 36 (2). pp. 253-263.

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It is well known that water molecules play an indispensable role in the structure and function of biological macromolecules. The water-mediated ionic interactions between the charged residues provide stability and plasticity and in turn address the function of the protein structures. Thus, this study specifically addresses the number of possible water-mediated ionic interactions, their occurrence, distribution and nature found in 90% non-redundant protein chains. Further, it provides a statistical report of different charged residue pairs that are mediated by surface or buried water molecules to form the interactions. Also, it discusses its contributions in stabilizing various secondary structural elements of the protein. Thus, the present study shows the ubiquitous nature of the interactions that imparts plasticity and flexibility to a protein molecule.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Plasticity and flexibility;protein complexes;protein-protein interactions;structure packing and stability;water-mediated ionic interactions
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Depositing User: Id for Latest eprints
Date Deposited: 29 Jun 2011 09:06
Last Modified: 16 Oct 2018 07:21
URI: http://eprints.iisc.ac.in/id/eprint/38627

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