Prediction of separation factor in foam separation of proteins

Bhattacharjee, Samita and Kumar, R and Gandhi, KS (1997) Prediction of separation factor in foam separation of proteins. In: Chemical Engineering Science, 52 (24). pp. 4625-4636.

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Abstract

A phenomenological model has been developed for predicting separation factors obtained in concentrating protein solutions using batch-foam columns. The model considers the adsorption of surface active proteins onto the air-water interface of bubbles, and drainage of liquid from the foam, which are the two predominant processes responsible for separation in foam columns. The model has been verified with data collected on casein and bovine serum albumin (BSA) solutions, for which adsorption isotherms are available in the literature. It has been found that an increase in liquid pool height above the gas distributor and the time allowed for drainage result in a better separation. Further, taller foam columns yield poorer separation at constant time of drainage. The model successfully predicts the observed results. (C) 1997 Elsevier Science Ltd.

Item Type:	Journal Article
Publication:	Chemical Engineering Science
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Foam;separation;proteins
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	02 Jul 2011 06:34
Last Modified:	02 Jul 2011 06:34
URI:	http://eprints.iisc.ac.in/id/eprint/38362

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