Spectroscopic studies on the interaction of Au(III) with nucleosides, nucleotides, and dimethyl phosphate

Chatterji, D and Nandi, US and Podder, SK (1977) Spectroscopic studies on the interaction of Au(III) with nucleosides, nucleotides, and dimethyl phosphate. In: Biopolymers, 16 (9). pp. 1863-1878.

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Abstract

A series of complexes of Au(III) with nucleosides and nucleotides and their methyl derivatives in different stoichiometry have been prepared. Ultraviolet, visible, ir, and nmr studies have been performed to determine the site of binding of these ligands with the metal ion. In (1:4) Au(III): guanosine complex, N7 is the binding site, whereas at 1:1 complex, a bidentate type of chelation through C6O and N7 is observed. C6-NH2 is favored over N1 as coordinating site at all stoichiometry in the adenosine complex. Inosine binds through N1 at r = 1. In cytidine, N1 is the binding site, whereas thymidine reacts only at high pH. In the case of nucleotides a bidentate type of chelation through the phosphate and the ring nitrogen occurs. The phosphate binding ability of Au(III) was further confirmed by studying the interaction of Au(III) with dimethyl phosphate - a conformational analog of the phosphate backbone in DNA chain.

Item Type:	Journal Article
Publication:	Biopolymers
Publisher:	John Wiley & Sons, Inc.
Additional Information:	Copyright of this article belongs to John Wiley & Sons, Inc.
Keywords:	Spectroscopic studies;nucleosides;nucleotides;dimethyl phosphate;gold
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Biological Sciences > Biochemistry
Date Deposited:	09 Jun 2004
Last Modified:	19 Sep 2010 04:12
URI:	http://eprints.iisc.ac.in/id/eprint/376

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