Synthesis, glucose uptake activity and structure-activity relationships of some novel glitazones incorporated with glycine, aromatic and alicyclic amine moieties via two carbon acyl linker

Kumar, Prashantha BR and Soni, Mukesh and Kumar, Santhosh S and Singh, Kuldeep and Patil, Mohan and Baig, Nasir RB and Adhikary, Laxmi (2011) Synthesis, glucose uptake activity and structure-activity relationships of some novel glitazones incorporated with glycine, aromatic and alicyclic amine moieties via two carbon acyl linker. In: European Journal of Medicinal Chemistry, 46 (3). pp. 835-844.

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Abstract

Three series of novel glitazones were designed and prepared by using appropriate synthetic schemes to incorporate glycine, aromatic and alicyclic amines via two carbon linker. Compounds were synthesized both under conventional and microwave methods. Nineteen out of twenty four synthesized compounds were evaluated for their in vitro glucose uptake activity using isolated rat hemi-diaphragm. Compounds, 6, 9a, 13a, 13b, 13c, 13f and 13h exhibited significant glucose uptake activity. Illustration about their synthesis and in vitro glucose uptake activity is described along with the structure activity relationships. (C) 2010 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	European Journal of Medicinal Chemistry
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Glitazones;Thiazolidinediones;Glucose uptake activity; Antidiabetic activity
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	20 Apr 2011 05:58
Last Modified:	20 Apr 2011 05:58
URI:	http://eprints.iisc.ac.in/id/eprint/36751

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