Srikrishna, A and Sharma, GVR and Nagaraju, S (1992) Chronic suppression of testicular function by constant infusion of gonadotropin-releasing hormone agonist and testosterone supplementation in the bonnet monkey (Macaca radiata). In: Fertility and Sterility, 57 (3). pp. 671-676.
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Objective: To study the efficacy of long-term buserelin acetate infusion to desensitize pituitary and block testicular function in adult male monkeys (Macaca radiata). Animals: Proven fertile male monkeys exhibiting normal testicular function. Protocol: Each of the control (n = 5) and experimental monkeys (n = 10) received a fresh miniosmotic pump every 21 days, whereas pumps in controls delivered vehicle of experimentals released 50-mu-g buserelin acetate every 24 hours. On day 170 (renewed every 60 days) a silastic capsule containing crystalline testosterone (T) was implanted in the experimental monkeys. At the end of 3 years, treatment was stopped, and recovery of testicular function and fertility monitored. Results: (1) Treatment resulted in marked reduction of nocturnal but not basal serum T; (2) the pituitary remained desensitized to buserelin acetate throughout the 3-year period; (3) animals were largely azoospermic with occasional oligospermia exhibited by two monkeys; and (4) withdrawal of treatment restored testicular function, with 70% of animals regaining fertility. Conclusion: Long-term infertility (but restorable) can be induced in male monkeys by constant infusion of buserelin acetate and T.
| Item Type: | Journal Article |
|---|---|
| Publication: | Fertility and Sterility |
| Publisher: | Elsevier science |
| Additional Information: | Copyright of this article belongs to Elsevier science. |
| Keywords: | Male Infertility;Buserelin;Pituitary Desensitization;Monkey Testicular Function. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 25 Jan 2011 06:45 |
| Last Modified: | 25 Jan 2011 06:45 |
| URI: | http://eprints.iisc.ac.in/id/eprint/35131 |
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