Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus

Gupta, Sarika and Chattopadhyay, Tandrika and Singh, Mahendra Pal and Surolia, Avadhesha (2010) Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus. In: Proc Natl Acad Sci Unit States Am, 107 (30). pp. 13246-13251.

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Abstract

Diabetes is a chronic disease requiring continuous medical supervision and patient education to prevent acute secondary complications. In this study, we have harnessed the inherent property of insulin to aggregate into an oligomeric intermediate on the pathway to amyloid formation, to generate a form that exhibits controlled and sustained release for extended periods. Administration of a single dose of the insulin oligomer, defined here as the supramolecular insulin assembly II (SIA-II), to experimental animals rendered diabetic by streptozotocin or alloxan, released the hormone capable of maintaining physiologic glucose levels for > 120 days for bovine and > 140 days for recombinant human insulin without fasting hypoglycemia. Moreover, the novel SIA-II described here not only improved the glycemic control, but also reduced the extent of secondary diabetic complications.

Item Type:	Journal Article
Publication:	Proc Natl Acad Sci Unit States Am
Publisher:	National Academy of Sciences
Additional Information:	Copyright of this article belongs to National Academy of Sciences.
Keywords:	protein folding; hyperglycemia; normoglycemia; insulin-like growth factor-1.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	15 Sep 2010 11:48
Last Modified:	19 Sep 2010 06:16
URI:	http://eprints.iisc.ac.in/id/eprint/32117

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