Biosynthesis of sulfated mucopolysaccharides in relation to vitamins A and K

Perumal, AS and Anantha Samy, TS and Lakshmanan, MR and Jungalwala, FB and Rao, PB Rama (1966) Biosynthesis of sulfated mucopolysaccharides in relation to vitamins A and K. In: Biochimica et Biophysica Acta (BBA) - General Subjects, 124 (1). pp. 95-100.

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Abstract

1.(1) Incorporation of Na235SO4 into acid mucopolysaccharides of intestine and colon tissue has been studied in normal, vitamin A-deficient and excess vitamin A-fed rats. 2. (2) Vitamin A deficiency resulted in a significant decrease in [35S]sulfate incorporation into mucopolysaccharides isolated from intestines of male rats. There was no significant change in the total mucopolysaccharides per gram of fresh tissue. 3. (3) When rats are fed excessive amounts of retinyl acetate, increased [35S]sulfate incorporation into mucopolysaccharides of rat intestine and colon is observed. 4. (4) Supplementation of vitamin K1 to rats fed excessive amounts of vitamin A restores the incorporation of [35S]sulfate into the acid mucopolysaccharides to the normal level. 5. (5) The implications of these findings with special reference to the role of vitamins A and K in the synthesis of sulfated mucopolysaccharides are discussed.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	18 May 2010 05:29
Last Modified:	19 Sep 2010 06:06
URI:	http://eprints.iisc.ac.in/id/eprint/27885

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