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Gene modulation and immunoregulatory roles of Interferon gamma

Saha, Banishree and Prasanna, S. Jyothi and Chandrasekar, Bhagawat and Nandi, Dipankar (2010) Gene modulation and immunoregulatory roles of Interferon gamma. In: Cytokine, 50 (1). pp. 1-14.

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Official URL: http://dx.doi.org/10.1016/j.cyto.2009.11.021


Interferon-gamma (IFN gamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Phosphorylated STAT1 homodimers translocate to the nucleus, bind to Gamma Activating Sequence (GAS) and recruit additional factors to modulate gene expression. A bioinformatics analysis revealed that greater number of putative promoters of immune related genes and also those not directly involved in immunity contain GAS compared to response elements (RE) for Interferon Regulatory Factor (IRF)1, Nuclear factor kappa B (NF kappa B) and Activator Protein (AP)1. GAS is present in putative promoters of well known IFN gamma-induced genes, IRF1, GBP1, CXCL10, and other genes identified were TLR3, VCAM1, CASP4, etc. Analysis of three microarray studies revealed that the expression of asubset of only GAS containing immune genes were modulated by IFN gamma. As a significant correlation exists between GAS containing immune genes and IFN gamma-regulated gene expression, this strategy may identify novel IFN gamma-responsive immune genes. This analysis is integrated with the literature on the roles of IFN gamma in mediating a plethoraof functions: anti-microbial responses, antigen processing,inflammation, growth suppression, cell death, tumor immunity and autoimmunity. Overall, this review summarizes our present knowledge onIFN gamma mediated signaling and functions. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Cytokine
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: IFN gamma;Gene expression;GAS;Signaling;Immune response
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 09 Jun 2010 07:07
Last Modified: 19 Sep 2010 05:59
URI: http://eprints.iisc.ac.in/id/eprint/27006

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