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A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium

Maddani, Mahagundappa R and Prabhu, Kandikere R (2010) A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium. In: Journal of Organic Chemistry, 75 (7). pp. 2327-2332.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo1001593


An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such Lis airlines and carbon disulfide in aqueous medium is presented. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives. The present method is also useful ill synthesizing various substituted 2-mercapto imidazole heterocycles. This method proceeds through a xanthate (amino dithiol deivative) intermediate, unlike isothiocyanate as in all earlier known method.

Item Type: Journal Article
Additional Information: Copyrigh of this article belongs to American Chemical Society.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Ms G Yashodha
Date Deposited: 09 Jun 2010 08:57
Last Modified: 19 Sep 2010 05:59
URI: http://eprints.iisc.ac.in/id/eprint/26999

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