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Novel Conformationally Locked Inositols:From Aromatics to Annulated Cyclitols

Mehta, Goverdhan and Ramesh, Senaiar S and Bera, Mrinal K (2003) Novel Conformationally Locked Inositols:From Aromatics to Annulated Cyclitols. In: Chemistry - A European Journal, 9 (10). pp. 2264-2272.


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A new family of ring-annulated inositols with lockedconformations has been designed to deliver a range of these biologically important entities in unnatural conformations while retaining their natural configurations.The simple tool of trans ring fusion has been used to lock the conformation of the annulated inositols. Short, simple syntheses of a range of these novel cyclitols have been achieved from readily available aromatic precursors such as tetralin and indane. Along the way, annulated C2-symmetric cyclohexadiene-trans-diol (trans-CHD) derivatives have been prepared for the first time and serve as the pivotal building blocks for generating the oxy- functionalization pattern of inositols. The presence of chemo-differentiated hydroxyl groups in our novel inositols is expected to facilitate the installation of phosphate diversity to harness the biological potential of these entities.

Item Type: Journal Article
Publication: Chemistry - A European Journal
Publisher: Wiley-VCH
Additional Information: Copyright for this article belongs to Wiley-VCH.
Keywords: annulation;conformation analysis;cyclitols;dihydroxylation;signal transduction
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 03 Feb 2005
Last Modified: 19 Sep 2010 04:17
URI: http://eprints.iisc.ac.in/id/eprint/2664

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