ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

How Effective Is The Data On Co-Occurrence Of Domains In Multi-Domain Proteins In Prediction Of Protein-Protein Interactions?

Mohanty, Smita and Srinivasan, N (2009) How Effective Is The Data On Co-Occurrence Of Domains In Multi-Domain Proteins In Prediction Of Protein-Protein Interactions? In: 7th IEEE International Workshop on Genomic Signal Processing and Statistics, MAY 17-19, 2009, Minneapolis.

[img] PDF
getPDF.pdf_3.pdf - Published Version
Restricted to Registered users only

Download (247kB) | Request a copy
Official URL: http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumb...

Abstract

We explore the fuse of information on co-occurrence of domains in multi-domain proteins in predicting protein-protein interactions. The basic premise of our work is the assumption that domains co-occurring in a polypeptide chain undergo either structural or functional interactions among themselves. In this study we use a template dataset of domains in multidomain proteins and predict protein-protein interactions in a target organism. We note that maximum number of correct predictions of interacting protein domain families (158) is made in S. cerevisiae when the dataset of closely related organisms is used as the template followed by the more diverse dataset of bacterial proteins (48) and a dataset of randomly chosen proteins (23). We conclude that use of multi-domain information from organisms closely-related to the target can aid prediction of interacting protein families.

Item Type: Conference Paper
Additional Information: Copyright of this article belongs to IEEE
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Users 920 not found.
Date Deposited: 26 Mar 2010 07:08
Last Modified: 19 Sep 2010 05:58
URI: http://eprints.iisc.ac.in/id/eprint/26549

Actions (login required)

View Item View Item