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Ultrasound-Triggered Controlled Drug Delivery and Biosensing Using Silica Nanotubes

Kapoor, Shobhna and Bhattacharyya, Aninda J (2009) Ultrasound-Triggered Controlled Drug Delivery and Biosensing Using Silica Nanotubes. In: Journal of Physical Chemistry C, 131 (17). 7155 -7163.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jp9000863

Abstract

Silica nanotubes (SNTs) have been demonstrated here as a versatile host for controlled drug delivery and biosensing. The sol-gel template synthesized SNTs have a slow rate of drug release. Application of an external stimulus in the form of ultrasound to or chemical functionalization of synthesized SNT results in higher yield of drug release as well as yield of drug release varying linearly with time. In case of controlled drug delivery triggered by ultrasound, drug yield as function of time is found to be heavily dependent on the ultrasound impulse protocol. Impulses of shorter duration (similar to 0.5 min) and shorter time intervals between successive impulses resulted in higher drug yields. Confinement of hemoglobin (Hb) inside nanometer sized channels of SNT does not have any detrimental effect on the native protein structure and function. Observance of significant enhancement in direct electron transfer of Hb makes the SNTs also promising for application in biosensors.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Ms S Jalajakshi
Date Deposited: 11 Jun 2010 07:37
Last Modified: 19 Sep 2010 05:57
URI: http://eprints.iisc.ac.in/id/eprint/26196

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