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Evolutionary Significance of Self-acylation Property in Acyl Carrier Proteins

Misra, Ashish and Surolia, Namita and Surolia, Avadhesha (2009) Evolutionary Significance of Self-acylation Property in Acyl Carrier Proteins. In: IUBMB Life, 61 (8). pp. 853-859.

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Official URL: http://www3.interscience.wiley.com/journal/1225147...


Acyl carrier protein is an integral component of many cellular metabolic processes. A number of studies have reported self-acylation behavior in acyl carrier proteins. Although AM exhibit high levels of similarity in their primary and tertiary structures, self-acylation behavior is restricted to only some ACPs that can be classified into two major families based on their function. The first family of ACPs is involved in polyketide biosynthesis, whereas the second family participates in fatty acid synthesis. Facilitated by the growing number of genome sequences available for analyses, large-scale phylogenetic studies were used in these studies to uncover as to how self-acylation behavior of acyl carrier proteins is linked with the evolution of metabolic pathways in organisms. These studies show that self-acylation behavior in acyl carrier proteins was lost during the course of evolution, with certain organisms and organelles viz. plastids, retaining it for specified functions. (C) 2009 IUBMB IUBMB Life, 61(8): 853-859, 2009

Item Type: Journal Article
Additional Information: Copyright of this article belongs to IUBMB Life.
Keywords: acyl carrier protein • self-acylation • fatty acid synthesis • malonyl-CoA • Escherichia coli
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Users 920 not found.
Date Deposited: 08 Mar 2010 07:58
Last Modified: 19 Sep 2010 05:56
URI: http://eprints.iisc.ac.in/id/eprint/26015

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