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Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors

Rajan, Vinoth Babu V and DSilva, Patrick (2009) Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors. In: Functional & Integrative Genomics, 9 (4). pp. 433-446.

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Plants are sessile organisms that have evolved a variety of mechanisms to maintain their cellular homeostasis under stressful environmental conditions. Survival of plants under abiotic stress conditions requires specialized group of heat shock protein machinery, belonging to Hsp70:J-protein family. These heat shock proteins are most ubiquitous types of chaperone machineries involved in diverse cellular processes including protein folding, translocation across cell membranes, and protein degradation. They play a crucial role in maintaining the protein homeostasis by reestablishing functional native conformations under environmental stress conditions, thus providing protection to the cell. J-proteins are co-chaperones of Hsp70 machine, which play a critical role by stimulating Hsp70s ATPase activity, thereby stabilizing its interaction with client proteins. Using genome-wide analysis of Arabidopsis thaliana, here we have outlined identification and systematic classification of J-protein co-chaperones which are key regulators of Hsp70s function. In comparison with Saccharomyces cerevisiae model system, a comprehensive domain structural organization, cellular localization, and functional diversity of A. thaliana J-proteins have also been summarized. Electronic supplementary material The online version of this article (doi:10.1007/s10142-009-0132-0) contains supplementary material, which is available to authorized users.

Item Type: Journal Article
Publication: Functional & Integrative Genomics
Publisher: Springer
Additional Information: Copyright of this article belongs to Springer.
Keywords: Arabidopsis thaliana;Heat shock protein;Hsp70;J-protein;ATPase activity.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 29 Oct 2009 06:06
Last Modified: 19 Sep 2010 05:52
URI: http://eprints.iisc.ac.in/id/eprint/24827

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