Effect of some "strong" excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes

Lakshmanan, J and Padmanaban, G (1974) Effect of some "strong" excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes. In: Biochemical and Biophysical Research Communications, 58 (3). pp. 690-698.

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Abstract

"Strong" excitants of central neurones such as β N-oxalyl L α,β-diaminopropionic acid (ODAP), N-methyl-D-aspartic acid (NMDA) and kainic acid (KA) were found to inhibit the high affinity uptake of glutamate and aspartate in synaptosomes isolated from young rat brain. The potency of these "strong" excitants as convulsants appear to parallel their ability to inhibit glutamate uptake by synaptosomes. The data suggest the possibility that the convulsive effect of these "strong" excitants could be mediated by glutamate/aspartate.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	18 Dec 2009 07:48
Last Modified:	19 Sep 2010 05:48
URI:	http://eprints.iisc.ac.in/id/eprint/23908

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