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Preparation, properties and metabolism of retinoic acid anhydride.

Premachandra, BR and Cama, HR (1975) Preparation, properties and metabolism of retinoic acid anhydride. In: International Journal for Vitamin and Nutrition Research, 45 (3). pp. 305-316.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/1184296

Abstract

A new analogue of vitamin A, viz., retinoic acid anhydride was prepared, for the first time, by the action of thionyl chloride on retinoic acid in benzene containing pyridine. The amhydride was charcterised by its chromatographic properties, elemental analysis, ultraviolet absorption, infrared and nuclear magnetic resonance spectral characteristics. The compound could be readily hydrolysed to retinoic acid both by acid and alkali treatments and reduced by lithium aluminium hydride to vitamin A alcohol (retinol). The spectral changes with antimony trichloride reagent were similar to those observed for retinoic acid. The metabolism of retinoic acid anhydride was found to be similar to that of retinoic acic. When administered either orally or intraperitoneally, the compound promotes growth in vitamin A-deficient rats. Time-course experiments revealed that retinoic acid anhydride is converted into retinoic acid by non-enzymatic hydrolysis and thereby exerts its biological activity. The biopotency of the anhydride was found to be nearly the same as that of the acid. A new method of preparing esters of retinoic acid employing retinoic acid anhydride as an intermediate, has been described.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Verlag Hans Huber.
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: K.S. Satyashree
Date Deposited: 03 Feb 2010 06:13
Last Modified: 03 Feb 2010 06:13
URI: http://eprints.iisc.ac.in/id/eprint/23897

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