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Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria

Mittal, Balraj and Kurup, CK Ramakrishna (1980) Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria. In: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 619 (1). pp. 90-97.

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The enzyme carnitine acetyltransferase (acetyl-CoA:carnitine O-acetyltransferase, EC has been purified to homogeneity from hepatic mitochondria of clofibrate-fed rats. It is a protein of molecular weight 56 000 composed of two non-identical subunits of molecular weight 34 000 and 25 000. The enzyme is inhibited by palmityl-CoA as well as acetyl carnitine. The inhibition by fatty acyl-CoA is competitive with respect to both the substrates, carnitine and acetyl-CoA. The inhibition by acetylcarnitine is reversed by carnitine but not by acetyl-CoA.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: Clofibrate induction; Carnitine acetyltransferase; (Rat liver mitochondria)
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: pallab
Date Deposited: 28 Jan 2010 09:46
Last Modified: 19 Sep 2010 05:38
URI: http://eprints.iisc.ac.in/id/eprint/21610

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