Small local variations in B-form DNA lead to a large variety of global geometries which can accommodate most DNA-binding protein motifs

Marathe, Arvind and Karandur, Deepti and Bansal, Manju (2009) Small local variations in B-form DNA lead to a large variety of global geometries which can accommodate most DNA-binding protein motifs. In: BMC Structural Biology, 9 (24).

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Abstract

An important question of biological relevance is the polymorphism of the double-helical DNA structure in its free form, and the changes that it undergoes upon protein-binding. We have analysed a database of free DNA crystal structures to assess the inherent variability of the free DNA structure and have compared it with a database of protein-bound DNA crystal structures to ascertain the protein-induced variations.

Item Type:	Journal Article
Publication:	BMC Structural Biology
Publisher:	BioMed Central
Additional Information:	Copyright of this article belongs to BioMed Central.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	07 Jan 2010 09:59
Last Modified:	19 Sep 2010 05:36
URI:	http://eprints.iisc.ac.in/id/eprint/21141

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