Solution conformations of penta and heptapeptides containing repetitive α-aminoisobutyryl-Image -alanyl and α -aminoisobutyryl-Image -valyl sequences

Vijayakumar, EKS and Balaram, P (1983) Solution conformations of penta and heptapeptides containing repetitive α-aminoisobutyryl-Image -alanyl and α -aminoisobutyryl-Image -valyl sequences. In: Tetrahedron, 39 (16). pp. 2725-2731.

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Abstract

The presence of folded solution conformations in the peptides Boc-Ala-(Aib-Ala)2-OMe, Boc-Val-(Aib-Val) 2-OMe, Boc-Ala-(Aib-Ala)3-OMe and Boc-Val-(Aib-Val)3-OMe has been established by 270MHz 1H NMR. Intramolecularly H-bonded NH groups have been identified using temperature and solvent dependence of NH chemical shifts and paramagnetic radical induced broadening of NH resonances. Both pentapeptides adopt 310 helical conformations possessing 3 intramolecular H-bonds in CDCl3 and (CD3)2SO. The heptapeptides favour helical structures with 5 H-bonds in CDCl3. In (CD3)2SO only 4 H-bonds are readily detected.

Item Type:	Journal Article
Publication:	Tetrahedron
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	04 Feb 2010 07:08
Last Modified:	19 Sep 2010 05:32
URI:	http://eprints.iisc.ac.in/id/eprint/20418

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