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Chemical Modification Studies of Gelonin - Involvement of Arginine Residues in Biological-Activity

Srinivasan, Y and Ramprasad, MP and Surolia, A (1985) Chemical Modification Studies of Gelonin - Involvement of Arginine Residues in Biological-Activity. In: FEBS Letters, 192 (1). pp. 113-118.

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Abstract

Gelonin inhibits protein synthesis by inactivating the eukaryotic 60 S ribosomal subunit by an unknown mechanism. The protein was purified in high yield by a new method using Cibacron blue F3GA-Sepharose. Chemical modification studies reveal that arginine residues are essential for biological activity.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to Elsevier Science
Keywords: Ribosome inactivating protein; Protein synthesis; Toxin; Chemical modification
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Paramesha S
Date Deposited: 29 May 2009 09:09
Last Modified: 19 Sep 2010 05:31
URI: http://eprints.iisc.ac.in/id/eprint/20150

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