Denoising neural data with state-space smoothing: Method and application

Nalatore, Hariharan and Ding, Mingzhou and Rangarajan, Govindan (2009) Denoising neural data with state-space smoothing: Method and application. In: Journal of Neuroscience Methods, 179 (1). pp. 131-141.

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Abstract

Neural data are inevitably contaminated by noise. When such noisy data are subjected to statistical analysis, misleading conclusions can be reached. Here we attempt to address this problem by applying a state-space smoothing method, based on the combined use of the Kalman filter theory and the Expectation–Maximization algorithm, to denoise two datasets of local field potentials recorded from monkeys performing a visuomotor task. For the first dataset, it was found that the analysis of the high gamma band (60–90 Hz) neural activity in the prefrontal cortex is highly susceptible to the effect of noise, and denoising leads to markedly improved results that were physiologically interpretable. For the second dataset, Granger causality between primary motor and primary somatosensory cortices was not consistent across two monkeys and the effect of noise was suspected. After denoising, the discrepancy between the two subjects was significantly reduced.

Item Type:	Journal Article
Publication:	Journal of Neuroscience Methods
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	EM algorithm;Kalman smoothing.
Department/Centre:	Division of Physical & Mathematical Sciences > Mathematics
Date Deposited:	30 May 2009 07:26
Last Modified:	19 Sep 2010 05:30
URI:	http://eprints.iisc.ac.in/id/eprint/19878

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