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Cloning of the cDNA's encoding the rat mismatch repair genes MSH2 and MLH1 and their expression during spermatogenesis

Vani, RG and Rao, MRS (1997) Cloning of the cDNA's encoding the rat mismatch repair genes MSH2 and MLH1 and their expression during spermatogenesis. In: Gene, 185 (1). pp. 19-26.

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Abstract

A rat cDNA clone encoding the mismatch repair protein MSH2 has been isolated and characterized. The cDNA has an open reading frame of 2802 nucleotides in length coding for a protein of 933 amino acids (100 kDa). It shows significant homology to human and mouse MSH2. Northern blot analysis of rat MSH2 in the testes of rats of different ages showed maximum expression at 20 days, at which time the germ cells are undergoing premeiotic DNA replication. We observed down-regulation in the expression of rat MSH2 beyond 25 days by which time the germ cells have entered meiotic prophase.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Mr. S Muthuraja
Date Deposited: 14 Jul 2009 13:48
Last Modified: 14 Jul 2009 13:48
URI: http://eprints.iisc.ac.in/id/eprint/18706

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