Bioinorganic chemistry of anti-thyroid drugs: an unusual formation of a copper (II) complex

Roy, Gouriprasanna and Nethaji, Munirathinam and Mugesh, G (2006) Bioinorganic chemistry of anti-thyroid drugs: an unusual formation of a copper (II) complex. In: Inorganic Chemistry Communications, 9 (6). pp. 571-574.

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Abstract

We report the first example of a metal complex derived from the selenium analogue of the anti-thyroid drug methimazole (MSeI). The treatment of the diselenide form of Se-methimazole with copper (11) perchlorate leads to an unexpected deselenation reaction resulting in the formation of a novel copper (11) complex (7). Theoretical studies are performed on compounds 5 and 6 to understand the structural changes that take place at the imidazole moiety upon deselenation. In addition, glutathione peroxidase (GPx) behavior and lactoperoxidase (LPO) inhibition activities of complex 7 are described.

Item Type:	Journal Article
Publication:	Inorganic Chemistry Communications
Publisher:	Elsavier
Additional Information:	Copyright of this article belongs to Elsavier
Keywords:	Chemistry, Inorganic & Nuclear;anti-thyroid drugs; copper complex; DFT calculations; lactoperoxidase inhibition activity; methimazole; selenium;Iodothyronine Deiodinase; Selenium Analog; Crystal-Structure; Soft; Hydrotris(Methimazolyl)Borate; Methimazole; Mechanism; Peroxidase; Ligand; Hydrotris(Pyrazolyl)Borate
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	08 Dec 2008 07:25
Last Modified:	19 Sep 2010 04:54
URI:	http://eprints.iisc.ac.in/id/eprint/16900

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