Conformation of gramicidin-A in CTAB micellar media

Shobini, J and Mishra, AK and Chandra, Nagasuma (2003) Conformation of gramicidin-A in CTAB micellar media. In: Journal of Photochemistry and Photobiology B: Biology, 70 (2). pp. 117-124.

PDF sdarticle10.pdf - Published Version Restricted to Registered users only Download (349kB) | Request a copy

Abstract

Gramicidin A (gA) is a linear pentadecapeptide, which exhibits various conformations depending on the environment. The conformational behavior of gA in spherical and rod-shaped cationic micelles formed by cetyltrimethylammonium bromide (CTAB) surfactant has been studied using circular dichroism (CD) and fluorescence spectroscopy, and a probable structure of gramicidin A in CTAB media has been proposed. A CD study shows that gramicidin A assumes$\beta^{ 6.3}$ helical structure in cationic spherical as well as rod-shaped CTAB micellar media. Modeling studies show the flexibility of the side chain conformation particularly in tryptophan-9. Study of intrinsic fluorescence of tryptophans in gramicidin A indicates three distinct environments for the four-tryptophan

Item Type:	Journal Article
Publication:	Journal of Photochemistry and Photobiology B: Biology
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Gramicidin A;Fluorescence spectroscopy;Circular dichroism; Model
Department/Centre:	Division of Information Sciences (Doesn't exist now) > BioInformatics Centre
Date Deposited:	17 Dec 2008 05:14
Last Modified:	19 Sep 2010 04:53
URI:	http://eprints.iisc.ac.in/id/eprint/16676

Actions (login required)

View Item